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P53271

- COG2_YEAST

UniProt

P53271 - COG2_YEAST

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Protein

Conserved oligomeric Golgi complex subunit 2

Gene

COG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.2 Publications

GO - Biological processi

  1. CVT pathway Source: SGD
  2. ER to Golgi vesicle-mediated transport Source: SGD
  3. intra-Golgi vesicle-mediated transport Source: SGD
  4. macroautophagy Source: SGD
  5. peroxisome degradation Source: SGD
  6. retrograde transport, vesicle recycling within Golgi Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 2
Short name:
COG complex subunit 2
Alternative name(s):
Component of oligomeric Golgi complex 2
Protein SEC35
Gene namesi
Name:COG2
Synonyms:SEC35
Ordered Locus Names:YGR120C
ORF Names:G6324
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR120c.
SGDiS000003352. COG2.

Subcellular locationi

Golgi apparatus membrane 2 Publications; Peripheral membrane protein 2 Publications; Cytoplasmic side 2 Publications

GO - Cellular componenti

  1. extrinsic component of membrane Source: SGD
  2. Golgi transport complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Conserved oligomeric Golgi complex subunit 2PRO_0000213499Add
BLAST

Proteomic databases

MaxQBiP53271.
PaxDbiP53271.
PeptideAtlasiP53271.

Expressioni

Gene expression databases

GenevestigatoriP53271.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. The COG complex interacts with the Rab GTPase YPT1, the Glogi SNAREs GOS1, SEC22, SED5, VTI1 and YKT6 and the COPI coatomer subunit gamma SEC21.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COG1P530798EBI-16614,EBI-4835
COG3P4009412EBI-16614,EBI-16605
COG4Q0609611EBI-16614,EBI-4823
COG5P539513EBI-16614,EBI-4841
COG6P539593EBI-16614,EBI-4829
COG7P531952EBI-16614,EBI-4847
COG8Q046324EBI-16614,EBI-6035
SED5Q015902EBI-16614,EBI-16930

Protein-protein interaction databases

BioGridi33365. 90 interactions.
DIPiDIP-1194N.
IntActiP53271. 29 interactions.
MINTiMINT-376961.
STRINGi4932.YGR120C.

Structurei

Secondary structure

1
262
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi110 – 12718Combined sources
Helixi133 – 15119Combined sources
Beta strandi154 – 1574Combined sources
Helixi158 – 17720Combined sources
Helixi184 – 20825Combined sources
Helixi214 – 24330Combined sources
Turni245 – 2484Combined sources
Helixi249 – 25810Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JQQNMR-A61-262[»]
ProteinModelPortaliP53271.
SMRiP53271. Positions 109-262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53271.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41082.
HOGENOMiHOG000111879.
InParanoidiP53271.
OMAiRESETNG.
OrthoDBiEOG7P5TBF.

Family and domain databases

InterProiIPR024602. COG_su2_N.
[Graphical view]
PfamiPF06148. COG2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53271 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLNDDELD LDLPVTAEIS KELFATEIEK YRESETNGTD VDNFDVDRFL
60 70 80 90 100
VQKNFHYLPL DSLIRDLSGL SQKMVQTLLE QIRSNYDDYL TFSNTYTDEE
110 120 130 140 150
NETLINLEKT QSDLQKFMTQ LDHLIKDDIS NTQEIIKDVL EYLKKLDEIY
160 170 180 190 200
GSLRNHSQLT EALSLGKRLS KSLHEMCGIE PLEEEICSGL IEQLYKLITA
210 220 230 240 250
SRRILESCAD SNSPYIHHLR NDYQDLLQEF QISLKILTEK CLENPSSLQN
260
LSLTLVSIIK TA
Length:262
Mass (Da):30,325
Last modified:July 11, 2006 - v2
Checksum:i0ED457A7466F0F53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83099 Genomic DNA. Translation: CAA58155.1.
Z72905 Genomic DNA. Translation: CAA97130.1.
BK006941 Genomic DNA. Translation: DAA08212.1.
PIRiS55978.
RefSeqiNP_011635.2. NM_001181249.1.

Genome annotation databases

EnsemblFungiiYGR120C; YGR120C; YGR120C.
GeneIDi853017.
KEGGisce:YGR120C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83099 Genomic DNA. Translation: CAA58155.1 .
Z72905 Genomic DNA. Translation: CAA97130.1 .
BK006941 Genomic DNA. Translation: DAA08212.1 .
PIRi S55978.
RefSeqi NP_011635.2. NM_001181249.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JQQ NMR - A 61-262 [» ]
ProteinModelPortali P53271.
SMRi P53271. Positions 109-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33365. 90 interactions.
DIPi DIP-1194N.
IntActi P53271. 29 interactions.
MINTi MINT-376961.
STRINGi 4932.YGR120C.

Proteomic databases

MaxQBi P53271.
PaxDbi P53271.
PeptideAtlasi P53271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR120C ; YGR120C ; YGR120C .
GeneIDi 853017.
KEGGi sce:YGR120C.

Organism-specific databases

CYGDi YGR120c.
SGDi S000003352. COG2.

Phylogenomic databases

eggNOGi NOG41082.
HOGENOMi HOG000111879.
InParanoidi P53271.
OMAi RESETNG.
OrthoDBi EOG7P5TBF.

Enzyme and pathway databases

BioCyci YEAST:G3O-30827-MONOMER.

Miscellaneous databases

EvolutionaryTracei P53271.
NextBioi 972884.

Gene expression databases

Genevestigatori P53271.

Family and domain databases

InterProi IPR024602. COG_su2_N.
[Graphical view ]
Pfami PF06148. COG2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes."
    van Dyck L., Tettelin H., Purnelle B., Goffeau A.
    Yeast 13:171-176(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking."
    VanRheenen S.M., Cao X., Lupashin V.V., Barlowe C., Waters M.G.
    J. Cell Biol. 141:1107-1119(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
    Whyte J.R., Munro S.
    Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  6. "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins."
    Suvorova E.S., Duden R., Lupashin V.V.
    J. Cell Biol. 157:631-643(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COG COMPLEX, SUBUNIT.
  7. "Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p."
    Ram R.J., Li B., Kaiser C.A.
    Mol. Biol. Cell 13:1484-1500(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
  8. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  11. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
    Loh E., Hong W.
    J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
  12. "Structural analysis of conserved oligomeric Golgi complex subunit 2."
    Cavanaugh L.F., Chen X., Richardson B.C., Ungar D., Pelczer I., Rizo J., Hughson F.M.
    J. Biol. Chem. 282:23418-23426(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 61-262.

Entry informationi

Entry nameiCOG2_YEAST
AccessioniPrimary (citable) accession number: P53271
Secondary accession number(s): D6VUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3270 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3